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Math Colloquium

March 20, 2019

TITLE: Thick, thin, and 'sick' blood: insights from mathematical modeling

By: Dr. Erica Graham, Assistant Professor of Mathematics at Bryn Mawr College

ABSTRACT: Blood clotting, or coagulation, is an important process in preventing excessive bleeding. However, pathological clotting can block blood flow through the arteries and veins, in a process called thrombosis. Dangerous clotting is usually initiated by injury to the vessel wall (arteries) or by immune cell infiltration (veins). In the first part of this talk, we discuss a mathematical model of arterial thrombosis and treatment with warfarin, a common "blood thinner". In the second part, we modify the model to account for venous clot formation via immune-mediated mechanisms.  In both vessel types, we use simulation studies to examine thrombus formation under reduced blood flow conditions and discuss implications for clinical treatment.

Come join us on April 2nd at 11:45am in Sally 121