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Prof. Jones and Ghazal Stity (Biochemistry 2015)


stephen Dunham

Stephen Dunham | Associate Professor and Chair, Chemistry; Co-chair, Biochemistry

Office location: Collier 209
Office phone: 610-625-7103

B.S., Hamline University
Ph.D. in Chemistry, Montana State

Research Interests
Biochemistry, NMR spectroscopy, metal interactions with DNA

Biochemistry Courses Taught
BIOL/CHEM 327 (Biochemistry I) and BIOL/CHEM 375.2 (Senior Seminar in Biochemistry)

Shari U. Dunham, Todd S. Remaley*, Bryn L. Moore*, Debra L. Evans* and Stephen U. Dunham, “Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh2(µ-L)(HNOCCF3)3 where L= [OOCCH3]-, [OOCCF3]-, [HNOCCF3]-“, Inorganic Chemistry 50(8), pp 3458-3463 (2011).

Cecilia Fox

Cecilia M. Fox | Professor and Chair, Biological Sciences; Director of the Neuroscience Program; Co-chair, Biochemistry

Office location: PPHAC 220
Lab location: Collier 320
Office phone: 610-861-1426

B.S. in Biology, Manhattan College
Ph.D. in Neurobiology and Anatomy, University of Kentucky

Research Interests
I teach Neuroscience (BIOL263), Introduction to Neuroscience Methods (NEUR 367), Neuroscience Seminar (NEUR373), Brain Sex (NEUR218), Anatomy and Physiology (BIOL103–104), Human Physiology (BIOL350) and Histology (BIOL345). My research focuses on the neuroprotection of the nigrostriatal pathway in a rodent model of Parkinson's disease. My undergraduates and I examine the efficacy of several antioxidants and growth factors in protecting dopamine neurons of the midbrain from the degeneration typically observed in this lesion model.

Halasz S., R. Stowell, and C.M. Fox "DNSP-11 is protective in the MPP+ and TaClo models of Parkinson's disease." In preparation.

McCambridge T., J. daSilva, N. Hadeed, and C.M. Fox "Dietary selenium protects dopamine levels and has the potential to improve motor behavior in the 6-hydroxydopamine rodent." In preparation.

Fox C.M. 2015. "Developing the next generation of civic-minded neuroscience scholars: Incorporating service learning and advocacy throughout a neuroscience program." Journal of Undergraduate Neuroscience Education 14(1): A23–A28.

Fox C.M. 2014. "Engaging neuroscience undergraduates in advocacy." Faculty for Undergraduate Neuroscience Quarterly 2(2):3–5.

Fox C.M. 2010. "Cow brains and sheep brains and rat brains, oh my! Using service learning to educate the public about the benefits of animal research."Research Saves 2(10):24–25.

Fox C.M. 2007. "Brain Awareness Day: Integrating service with classroom instruction in neuroscience." Journal of College Science Teaching 37(2): 40-45.

Mueller S., M. Drost, and C.M. Fox 2007. "Dietary and intraperitoneal administration of selenium provide comparable protection in the 6-hydroxydopamine lesion rat model of Parkinson’s disease." IMPULSE 2:1–10.

Fox C.M. 2004 "The positive outcomes of student involvement in Brain Awareness Day, 2004." Proceedings of the Best Practices in Higher Education, November issue: 19–21.

Fox C.M., D.M. Gash, M.K. Smoot and W.A. Cass. 2001. "Neuroprotective effects of GDNF against 6-OHDA in young and aged rats." Brain Research 896(1–2):56–63.

Fox C.M. and R. Alder. 2000. "Neural Mechanisms of Aging," Neuroscience for Rehabilitation, 2nd edition, Lippincott Williams & Wilkins.



Michael Bertucci | Assistant Professor, Chemistry

Office location: Collier 222
Office phone: 610-861-1436

B.S., Stevens Institute of Technology
Ph.D., University of North Carolina at Chapel Hill

Research Interests
My academic interests include Bioorganic Chemistry, Synthetic Organic Chemistry, Peptide Chemistry, & Chemical Biology. Current research projects include development of small molecules and peptides for the study and inhibition of bacterial quorum sensing.

Biochemistry Courses Taught
CHEM 211 and 212 (Organic Chemistry I and II)

Bertucci, M. A. and March, K.*, Non-Natural D-Amino Acids to Control Bacterial Virulence.Proceedings of the 24th American Peptide Symposium, 2015, 51 – 53.

Bertucci, M. A., Lee, S. J., Gagné, M. R., Selective Transamidation of 3-oxo-N-Acyl Homoserine Lactones by Hydrazine Derivatives. Org. Biomol. Chem., 2014, 12, 7197 – 7200.

Bertucci, M. A., Lee, S. J., Gagné, M. R., Thiourea-catalyzed aminolysis of N-acyl homoserine lactonesChem. Commun., 2013, 49, 2055-2057.

shari Dunham

Shari Uldrich Dunham | Associate Professor, Chemistry

Office location: Collier 213
Office phone: 610-625-7105

B.A. in Chemistry, Drew University
Ph.D in Chemistry, Massachusetts Institute of Technology

Research Interests
As a biochemistry researcher, I continue to explore the DNA interactions of novel dirhodium compounds with potential anticancer activity. As an educator I am exploring two areas that affect student learning: (1) the impact of guided-inquiry activities on student development of molecular visualization skills in Biochemistry and (2) development of quantitative skill interventions to improve student success in Introductory Chemistry. Dr.

Biochemistry Courses Taught
CHEM 113 (General Chemistry) and BIOL/CHEM 327 (Biochemistry I)

Shari U. Dunham, Todd S. Remaley*, Bryn L. Moore*, Debra L. Evans* and Stephen U. Dunham, “Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh2(µ-L)(HNOCCF3)3 where L= [OOCCH3]-, [OOCCF3]-, [HNOCCF3]-“, Inorganic Chemistry 50(8), pp 3458-3463 (2011).

Shari U. Dunham, Amity E. Burr*, Szymon Mikulski,* Helen Chifotides and Kim Dunbar, “Covalent Binding and Interstrand Cross-Linking of Duplex DNA by Dirhodium(II,II) Carboxylate Compounds”, Biochemistry 44(3), pp 996-1003 (2005).

Mark D. Finke, Shari U. Dunham and Christabel Kwabi*, “Evaluation of four dry commercial gut loading products for improving the calcium content of crickets, Acheta domesticus”, J. of Herp. Medicine and Surgery, 15(1), pp 7-12 (2005).

Mark D. Finke, Shari U. Dunham and John S. Cole III*, “Evaluation of various commercial products for improving the calcium content of crickets, Acheta domesticus”, J. of Herp. Medicine and Surgery, 14(2), pp 6-9 (2004).

Diane Winn, Shari Dunham and Szymon Mikulski*, “Food for Insects and Insects as Food: Viable Strategies for Achieving Adequate Calcium”, J. of Wildlife Rehabilitation, 26(1), 4-13 (2003).

Daniel S. Pilch, Shari U. Dunham, Elizabeth R. Jamieson, Stephen J. Lippard and Kenneth Breslauer, "DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA", J. Mol. Bio., 29, 6803-812 (2000).

Shari U. Dunham, Stephen U. Dunham, Christopher J. Turner and Stephen J. Lippard, “Solution structure of a DNA duplex containing a nitroxide spin-labeled platinum d(GpG) intrastrand cross-link refined with NMR-derived long range electron-proton distance restraints”, J. Am. Chem. Soc., 120, 5395-5406 (1998).

Shari U. Dunham and Stephen J. Lippard, “DNA sequence context and protein composition modulate HMG-domain protein recognition of cisplatin-modified DNA”, Biochemistry, 36, 11428-11436 (1997).

Natasa Poklar, Daniel S. Pilch, Stephen J. Lippard, Elizabeth A. Redding, Shari U. Dunham and Kenneth J. Breslauer, “Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex”, Proc. Nat. Acad. Sci., USA, 93, 7606-7611 (1996).

chris jones

Christopher Jones | Professor and Chair, Biological Sciences; Co-Chair, Biochemistry

Office location: Collier 319
Lab location: Collier 227
Office phone: 610-861-1614

B.A. in Biology and Russian, Haverford College
M.Phil. in Molecular Biophysics & Biochemistry, Yale University
Ph.D. in Molecular Biophysics & Biochemistry, Yale University

Research Interests
I'm interested in many aspects of molecular genetics, but my research focuses primarily on the genetics of behavior in the fruit fly Drosophila melanogaster, especially learning and memory as well as seizure disorders.

Biochemistry Courses Taught
BIOL 210 (Genetics) and BIOL 365 (Molecular Genetics)

Lopatto D., C. Alvarez, D. Barnard, C. Chandrasekaran, H.-M. Chung, C. Du, T. Eckdahl, A.L. Goodman, C. Hauser, C.J. Jones, O.R. Kopp, G.A. Kuleck, G. McNeil, R. Morris, J.L. Myka, A. Nagengast, P.J. Overvoorde, J.L. Poet, K. Reed, G. Regisford, D. Revie, A. Rosenwald, K. Saville, M. Shaw, G.R. Skuse, C. Smith, M. Smith, M. Spratt, J. Stamm, J.S. Thompson, B.A. Wilson, C. Witkowski, J. Youngblom, W. Leung, C.D. Shaffer, J. Buhler, E. Mardis, and S.C.R. Elgin. 2008. "Genomics Education Partnership." Science  322(5902):684–685.

Joiner, M.A., Z. Asztalos, C.J. Jones, T. Tully, and C.-F. Wu. 2007. "Effects of MutantDrosophila K+ Channel Subunits on Habituation of the Olfactory Jump Response." Journal of Neurogenetics 21(1):45–58.

Nowotny, P., S.M. Gorski, S.W. Han, K. Philips, W.J. Ray, V. Nowotny, C.J. Jones, R.F. Clark, R.L. Cagan, and A.M. Goate. 2000. "Posttranslational Modification and Plasma Membrane Localization of the Drosophila melanogaster Presenilin." Molecular and Cellular Neuroscience 15(1):88–98.

Pinto S., D.G. Quintana, P. Smith, R.M. Mihalek, Z.H. Hou, S. Boynton, C.J. Jones, M. Hendricks, K. Velinzon, J.A. Wohlschlegel, R.J. Austin, W.S. Lane, T. Tully, and A. Dutta. 1999. "latheo encodes a subunit of the origin recognition complex and disrupts neuronal proliferation and adult olfactory memory when mutant." Neuron 23(1):45–54.

Mihalek, R.*, C.J. Jones*, and T. Tully. 1997. "The Drosophila Mutation turnip has Pleiotropic Behavioral Effects and Does Not Specifically Affect Learning." Learning and Memory 3:425–444.
* Equal contributors


carl Salter

Carl Salter | Professor, Chemistry

Office location: Collier 221
Office phone: 610-625-7920

M.S. in Chemistry, Vanderbilt University
Ph.D in Chemistry, Vanderbilt University

Research Interests
Spectroscopy, electronic structure calculations, and statistical analysis of experimental data.

Biochemistry Courses Taught
CHEM 220.2 (Methods in Chemical Research) and CHEM 331 (Physical Chemistry I)

anastasia thevenin

Anastasia Thévenin | Assistant Professor

Office location: Collier 316
Office phone: 610-861-1607

B.S. in Biomedical Science, Lynchburg College
Ph.D. in Chemistry and Biochemistry, University of Delaware

Research Interests
I am interested in understanding how phosphorylation of Gap Junction (GJ) protein, Connexin 43 (Cx43), affects its function. GJs are pores found in plasma membranes of two neighboring cells and are made up of 12 Cx43 molecules. These pores are the only means cells have for direct cell-cell communication, allowing small molecules and ions to move from cell to cell. Cell-cell communication is key for many cellular functions, such as development, proliferation and differentiation. Current projects are focused on using phosphomimetic mutants of Cx43 to study their ability to interact with other protein partners and to affect GJ function.

Biochemistry Courses Taught
BIOL/CHEM 328 (Biochemistry II)

Janessa Gerhart, Anastasia F. Thévenin, Kelly King and Damian Thévenin. “Inhibiting EGFR Dimerization and Signaling Through Targeted Delivery of a Juxtamembrane Domain Peptide Mimic” ACS Chemical Biology 13 (9):2623-2632, 2018.

Anastasia F. Thévenin and Matthias M. Falk. "Consecutive phosphorylation/de-phosphorylation events at three connexin43 serine residues regulate accrual and transition of 'functional, ZO-1-bound' into 'closed' gap junction channels." In Preparation.

Catherine Chen*, Byung H. Ha*, Anastasia F. Thévenin, Hua J. Lou, Rong Zhang, Kevin Y. Yip, Jeffrey R. Peterson, Mark Gerstein, Philip M. Kim, Stefan Knapp, Titus J. Boggon, and Benjamin E. Turk. "Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity." Molecular Cell 53(1):140-7, 2014.
* equal author contribution

Anastasia F. Thévenin, Tia J. Kowal, John T. Fong, Rachael M. Kells, Charles G. Fisher, and Matthias M. Falk. "Proteins and Mechanisms Regulating Gap Junction Assembly, Internalization and Degradation." Physiology 28: 93-116, 2013.

Anastasia F. Thévenin, Chati L. Zony&, Brian J. Bahnson and Roberta F. Colman. "Activation by phosphorylation and purification of human c-Jun N-terminal kinase (JNK) isoforms in milligram amounts." Protein Expr Purif 75 :138-146, 2011.
& undergraduate student

Anastasia F. Thévenin, Chati L. Zony&, Brian J. Bahnson and Roberta F. Colman. "Requirements for complex formation between c-Jun N-terminal kinase and Glutathione S-Transferase in vitro." Protein Science 20 :834-848, 2011.
& undergraduate student

Anastasia F. Thévenin*, Elizabeth S. Monillas*, Jason M. Winget, Kirk Czymmek and Brian J. Bahnson. "Trafficking of Platelet-activating Factor Acetylhydrolase type-II in response to oxidative stress." Biochemistry 50:8417-8426, 2011.
* equal author contribution