Carl Salter | Professor, Chemistry
Office location: Collier 221
Office phone: 610-625-7920
M.S. in Chemistry, Vanderbilt University
Ph.D. in Chemistry, Vanderbilt University
Spectroscopy, electronic structure calculations, and statistical analysis of experimental data.
Shari Uldrich Dunham | Associate Professor, Chemistry
Office location: Collier 213
Office phone: 610-625-7105
B.A. in Chemistry, Drew University
Ph.D in Chemistry, Massachusetts Institute of Technology
As a biochemistry researcher, I continue to explore the DNA interactions of novel dirhodium compounds with potential anticancer activity. As a educator I am exploring two areas that affect student learning: (1) the impact of guided-inquiry activities on student development of molecular visualization skills in Biochemistry and (2) development of quantitative skill interventions to improve student success in Introductory Chemistry.
Shari U. Dunham, Todd S. Remaley*, Bryn L. Moore*, Debra L. Evans* and Stephen U. Dunham, “Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh2(µ-L)(HNOCCF3)3 where L= [OOCCH3]-, [OOCCF3]-, [HNOCCF3]-“, Inorganic Chemistry 50(8), pp 3458-3463 (2011).Shari U. Dunham, Amity E. Burr*, Szymon Mikulski,* Helen Chifotides and Kim Dunbar, “Covalent Binding and Interstrand Cross-Linking of Duplex DNA by Dirhodium(II, II) Carboxylate Compounds”, Biochemistry 44(3), pp 996-1003 (2005).
Mark D. Finke, Shari U. Dunham and Christabel Kwabi*, “Evaluation of four dry commercial gut loading products for improving the calcium content of crickets, Acheta domesticus”, J. of Herp. Medicine and Surgery, 15(1), pp 7-12 (2005).
Mark D. Finke, Shari U. Dunham and John S. Cole III*, “Evaluation of various commercial products for improving the calcium content of crickets, Acheta domesticus”, J. of Herp. Medicine and Surgery, 14(2), pp 6-9 (2004).
Diane Winn, Shari Dunham, and Szymon Mikulski*, “Food for Insects and Insects as Food: Viable Strategies for Achieving Adequate Calcium”, J. of Wildlife Rehabilitation, 26(1), 4-13 (2003).
Daniel S. Pilch, Shari U. Dunham, Elizabeth R. Jamieson, Stephen J. Lippard and Kenneth Breslauer, "DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA", J. Mol. Bio., 29, 6803-812 (2000).
Shari U. Dunham, Stephen U. Dunham, Christopher J. Turner and Stephen J. Lippard, “Solution structure of a DNA duplex containing a nitroxide spin-labeled platinum d(GpG) intrastrand cross-link refined with NMR-derived long range electron-proton distance restraints”, J. Am. Chem. Soc., 120, 5395-5406 (1998).
Shari U. Dunham and Stephen J. Lippard, “DNA sequence context and protein composition modulate HMG-domain protein recognition of cisplatin-modified DNA”, Biochemistry, 36, 11428-11436 (1997).
Natasa Poklar, Daniel S. Pilch, Stephen J. Lippard, Elizabeth A. Redding, Shari U. Dunham and Kenneth J. Breslauer, “Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex”, Proc. Nat. Acad. Sci., USA, 93, 7606-7611 (1996).
Stephen Dunham | Associate Professor, Chemistry & Department Chair
Office location: Collier 209
Office phone: 610-625-7103
B.S., Hamline University
Ph.D. in Chemistry, Montana State
My general area of research is in Bioinorganic chemistry. In particular, I am interested in the synthesis and reactivity of platinum group metals and their interactions with biomolecules. I routinely use nuclear magnetic resonance spectroscopy to characterize these systems.
Shari U. Dunham, Todd S. Remaley*, Bryn L. Moore*, Debra L. Evans* and Stephen U. Dunham, “Isolation, Characterization, and DNA Binding Kinetics of Three Dirhodium(II,II) Carboxyamidate Complexes: Rh2(µ-L)(HNOCCF3)3 where L= [OOCCH3]-, [OOCCF3]-, [HNOCCF3]-“, Inorganic Chemistry 50(8), pp 3458-3463 (2011).
Michael Bertucci | Assistant Professor, Chemistry
Office location: Collier 222
Office phone: 610-861-1436
B.S., Stevens Institute of Technology
Ph.D., University of North Carolina at Chapel Hill
My academic interests include bioorganic chemistry, synthetic organic chemistry, peptide chemistry, & chemical biology. Current research projects in my laboratory focus on the development of small molecules and peptides for the study and inhibition of bacterial quorum sensing.
Schmucker, D. J., Dunbar, S. R., Shepherd, T. D., Bertucci, M.A. n→pi* Interactions in N-Acyl Homoserine Lactone (AHL) Derivatives and Their Effects on Hydrolysis Rates. J. Phys. Chem. A., 2019, 123 (13), 2537 - 2543.
Koirala, B., Hillman, R. A., Tiwold, E. K., Bertucci, M. A., Tal-Gan, Y., Defining the Hydrophobic Interactions that Drive Competence Stimulating Peptide (CSP):ComD Binding in Streptococcus pneumoniae. Beilstein J. Org. Chem., 2018, 14, 1769 - 1777.
Hillman, R. A., Nadraws, J. W., Bertucci, M. A. The Hydrocarbon Staple & Beyond: Recent Advances Towards Stapled Peptide Therapeutics that Target Protein-Protein Interactions. Curr. Top. Med. Chem., 2018, 18, 611 - 624.
Bertucci, M. A., Lee, S. J., Gagné, M. R., Selective Transamidation of 3-oxo-N-Acyl Homoserine Lactones by Hydrazine Derivatives. Org. Biomol. Chem., 2014, 12, 7197 – 7200.
Bertucci, M. A., Lee, S. J., Gagné, M. R., Thiourea-catalyzed aminolysis of N-acyl homoserine lactones. Chem. Commun., 2013, 49, 2055-2057.
Alison Holliday | Associate Professor, Chemistry
Office location: Collier 220
Office phone: 610-861-1433
B.S.c, Queen's University
Ph.D., Queen's University
The focus of my research is on developing separation methods to investigate complex environmental and biological systems. We use liquid and gas chromatography and capillary electrophoresis to explore peptide folding, the distribution and fate of toxins in the environment, and the chemical defenses of insects.
A.E. Holliday, T.M. Mattingly,*, A.A. Toro*, L.J. Donald, and N.J. Holliday, Age- and sex-related variation in defensive secretions of adult Chlaenius cordicollis and evidence for their role in sexual communication, Chemoecology, 26, 107-119 (2016).
L. Shi, A.E. Holliday, M.S. Glover, M.A. Ewing, D.H. Russell, and D.E. Clemmer, Ion mobility-mass spectrometry reveals the energetics of intermediates that guide polyproline folding, Journal of the American Society for Mass Spectrometry, 27, 22-30 (2016).
John D. Barr, Liuqing Shi, David H. Russell, David E. Clemmer, and Alison E. Holliday, Following a folding transition with capillary electrophoresis and ion mobility spectrometery, Analytical Chemistry, 88, 10933-9 (2016).
Godfred Fianu | Laboratory Coordinator & Instructor
Office location: Collier 212
Office phone: 610-861-1379
Ph.D. Lehigh University
My research interests include Organometallic Chemistry, Physical Organic Chemistry with particular emphasis on titanocene based single-electron catalysis. My prior research was on the mechanistic studies of atom-economical titanocene-catalyzed homolytic aromatic substitution reactions and on titanocene borohydride-catalyzed reductions.
KeriLyn C. Burrows | Adjunct Professor
Office location: Collier 212
Office phone: 610-861-1629
As a chemist in the pharmaceutical industry for twenty years, I have been involved in formulation and lyophilization cycle development, as well as development of analytical methods (primarily high pressure liquid chromatography). More recently, I have concentrated on the most efficient way of writing basic analytical methods that may be used for multiple products and cover various compendia.
In the classroom, I am interested in exposing my students to challenges they will face in industry and helping them develop "soft" skills such as oral and written communication and interpersonal interactions.
Jie Floyd | Adjunct Professor
Office location: Collier 212
Office phone: 610-861-1386
My areas of academic interests are the implementation of molecular modeling analysis to develop pharmacophore models and enzyme kinetics. My research was focused on structure-based drug design by applying QSAR, quantum mechanics, molecular mechanics, diversity analysis, and other molecular modeling techniques.